Pulse Biosciences, Inc., formerly Electroblate, Inc., is a development-stage medical device company using a platform technology called Nano-Pulse Electro-Signaling (NPES). The Company’s NPES is a drug-free technology that utilizes nanosecond pulsed electric fields to induce cell signaling and the activation of cellular pathways in tissue. NPES induces a range of cellular responses, including secretion, apoptosis and necrosis by modulating the NPES pulses, making it applicable to a range of cell types and therapeutic applications. The Company is developing NPES as a treatment modality across a range of applications, including oncology, dermatology and other minimally invasive applications. The NPES pulses are applied directly to tissue, creating a transient opening of small pores in cell and organelle membranes. The Company produces natural cell death using NPES to initiate cell signaling that induces the targeted adaptive immune response.